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  4. PARK YONG DOO
PARK YONG DOO 教授
PI，教授，问题性皮肤研究中心主任

教育背景

  • 1992.03 - 1996.02   Chonnam National University(韩，全南国立大学)，本科生
  • 1996.09 - 1997.08   北京语言文化大学，进修生
  • 1997.09 - 2001.06   清华大学生物技术与工程系，研究生（硕博连读）
  • 2001.07 - 2001.12   哈佛大学医学院CBBSM中心，博士后

工作履历

  • 2018.05 -       浙江清华长三角研究院问题性皮肤研究中心，主任
  • 2006.05 -       浙江清华长三角研究院生物技术与医药研究所，PI
  • 2004.09 - 2016.08   成均馆大学医学院（韩），研究教授
  • 2002.01 - 2007.03   三星集团生物医药研究中心，首席研究员
  • 2008.01 - 2011.01   南方医科大学，特聘教授（兼职）

奖励与荣誉(市级及以上)

  1. 国家高端外国专家
  2. 浙江省“西湖友谊奖”
  3. 嘉兴市 “荣誉市民”
  4. 嘉兴市高层次外国专家
  5. 宁波市重点高层次人才
  6. 嘉兴市自然科学学术一等奖 （2012年）

承担重要项目

  1. 韩国2001健康研究与开发项目，韩国保健福祉部(01-PJ3-PG6-01GN12-0001)
  2. 韩国21世纪健康研究与开发项目，韩国保健福祉部(03-PJ10-PG6-GN01-002)
  3. 国家高端外国专家项目
  4. 创新嘉兴精英引领计划高层次外国专家项目

代表性著作及论文

Atopic dermatitis research （特应性皮炎研究）：

  1. Yin SJ, Cho IH, Yang HS, Park YD, Yang JM. Analysis of the peptides detected in atopic dermatitis and various inflammatory diseases patients-derived sera. Int J Biol Macromol. 2018 Jan;106:1052-1061.
  2. Hee Seung Yang, Ick-Hyun Cho, Qian Wang, Yong-Doo Park, Jun-Mo Yang. Serum proteomic analyses for probing C3 fragment protein. Process Biochemistry, Volume 51, Issue 8, August 2016, Pages 981-988.
  3. Shang-Jun Yin, Hee Seung Yang, Ick-Hyun Cho, Qian Wang, Yong-Doo Park, Jun-Mo Yang. An integrated method for the detection of basic proteins in serum-derived proteomes. Process Biochemistry, Volume 51, Issue 8, August 2016, Pages 973-980.
  4. Shang-Jun Yin, Daeui Park, Yue-Xiu Si, Hae Young Chung, Yong-Doo Park, Jun-Mo Yang. An RNA interference based study for the role of ALDH1 in keratinocytes: DNA microarray, antibody–chip array and bioinformatics approaches. Process Biochemistry, Volume 49, Issue 10, October 2014, Pages 1612-1621.
  5. Yin SJ, Si YX, Zhang M, Qian GY, Zhang F, Yan L, Lü ZR, Zhou HM, Yang HS, Park YD, Yang JM. Combination of free-flow electrophoresis and interactomics to analyze the dysregulated proteins of fibroblasts from atopic dermatitis patients. J Dermatol Sci. 2011 Feb;61(2):148-50.
  6. Park YD*, Park D, Bhak J, Yang JM. Proteomic approaches to the analysis of atopic dermatitis and new insights from interactomics. Proteomics Clin Appl. 2008 Mar;2(3):290-300.
  7. Park YD, Lyou YJ, Yang JM. Two-dimensional electrophoresis analyses of atopic dermatitis and the chances to detect new candidate proteins by the variations in immobilized pH gradient strips. J Dermatol Sci. 2007 Jul;47(1):9-17.
  8. Park YD, Lyou YJ, Yang JM. Detection of down-regulated acetaldehyde dehydrogenase 1 in atopic dermatitis patients by two-dimensional electrophoresis. Exp Dermatol. 2007 Feb;16(2):130-4.
  9. Park YD, Lyou YJ, Lee KJ, Lee DY, Yang JM. Towards profiling the gene expression of fibroblasts from atopic dermatitis patients: human 8K complementary DNA microarray. Clin Exp Allergy. 2006 May;36(5):649-57.
  10. Park YD, Jang HS, Kim SY, Ko SK, Lyou YJ, Lee DY, Paik YK, Yang JM. Two-dimensional electrophoretic profiling of atopic dermatitis in primary cultured keratinocytes from patients. Proteomics. 2006 Feb;6(4):1362-70.
  11. Park YD, Kim SY, Jang HS, Seo EY, Namkung JH, Park HS, Cho SY, Paik YK, Yang JM. Towards a proteomic analysis of atopic dermatitis: a two-dimensional-polyacrylamide gel electrophoresis/mass spectrometric analysis of cultured patient-derived fibroblasts. Proteomics. 2004 Nov;4(11):3446-55.

Pigmentation research （皮肤黑色素研究）：

  1. Proteomic analyses for profiling regulated proteins/enzymes by Fucus vesiculosus fucoidan in B16 melanoma cells: A combination of enzyme kinetics functional study.
  2. Wang ZJ, Zheng L, Yang JM, Kang Y, Park YD*. Int J Biol Macromol. 2018 Jun;112:667-674.
  3. Shang-Jun Yin, Kun-Yuan Liu, Jinhyuk Lee, Jun-Mo Yang, Guo-Ying Qian, Yue-Xiu Si, Yong-Doo Park*. Effect of hydroxysafflor yellow A on tyrosinase: Integration of inhibition kinetics with computational simulation. Process Biochemistry, Volume 50, Issue 12, December 2015, Pages 2112-2120.
  4. Wei Wang, Daeui Park, Sunyoung Ji, Shang-Jun Yin, Guo-Ying Qian, Hae Young Chung, Jun-Mo Yang, Jinhyuk Lee, Yong-Doo Park*. Computational prediction for the protein interactions of tyrosinase: Protein experimental interactome MAP. Process Biochemistry, Volume 48, Issue 4, April 2013, Pages 638-648.
  5. Si YX, Wang ZJ, Park D, Chung HY, Wang SF, Yan L, Yang JM, Qian GY, Yin SJ, Park YD*. Effect of hesperetin on tyrosinase: inhibition kinetics integrated computational simulation study. Int J Biol Macromol. 2012 Jan 1;50(1):257-62.
  6. Yin SJ, Si YX, Wang ZJ, Wang SF, Oh S, Lee S, Sim SM, Yang JM, Qian GY, Lee J, Park YD*. The effect of thiobarbituric acid on tyrosinase: inhibition kinetics and computational simulation. J Biomol Struct Dyn. 2011 Dec;29(3):463-70.
  7. Lü ZR, Seo E, Yan L, Yin SJ, Si YX, Qian GY, Park YD*, Yang JM. High-throughput integrated analyses for the tyrosinase-induced melanogenesis: microarray, proteomics and interactomics studies. J Biomol Struct Dyn. 2010 Oct;28(2):259-76.

部分授权专利、软件著作权及其他

  1. 特应性皮炎角质细胞或血清衍生的生物标志物（10-1109043）发明人：Yang Jun Mo（梁俊莫），Park Yong Doo（朴龙斗）
  2. 外源性特应性皮炎的生物标志物（10-1105811）发明人：Yang Jun Mo（梁俊莫），Park Yong Doo（朴龙斗）
  3. 普遍特应性皮炎的生物标志物（10-1117799）发明人：Yang Jun Mo（梁俊莫），Park Yong Doo（朴龙斗）
  4. 色素过多的生物标志物及其应用（10-1109739）发明人：Yang Jun Mo（梁俊莫），Park Yong Doo（朴龙斗）
  5. 三氟乙醇用于酪氨酸酶活性调控（10-1123149）发明人：Yang Jun Mo（梁俊莫），Park Yong Doo（朴龙斗）

其他

作为Lead Guest Editor在《Enzyme Research》杂志上出版了Special Issue: Skin diseases-related enzymes: mechanisms and clinical applications.